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dc.contributor.authorGram, Inger Torhild
dc.contributor.authorNorat, Teresa
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorDossus, Laure
dc.contributor.authorLukanova, Annekatrin
dc.contributor.authorTéhard, B
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorGils, C H van
dc.contributor.authorNoord, P A H van
dc.contributor.authorPeeters, Petra H M
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorNagel, Gabriele
dc.contributor.authorLinseisen, Jakob
dc.contributor.authorLahmann, Petra H
dc.contributor.authorBoeing, Heiner
dc.contributor.authorPalli, Domenico
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorSieri, Sabina
dc.contributor.authorDorronsoro Iraeta, Miren
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorNavarro, Carmen A
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorTormo, M-J
dc.contributor.authorGonzález, Carlos Alberto
dc.contributor.authorOvervad, Kim
dc.contributor.authorPaaske Johnsen, S
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTravis, R
dc.contributor.authorAllen, Naomi E
dc.contributor.authorBingham, Sheila A
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorStattin, P
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKalapothaki, V
dc.contributor.authorPsaltopoulou, Theodora
dc.contributor.authorCasagrande, Corinne
dc.contributor.authorRiboli, Elio
dc.contributor.authorKaaks, Rudolf
dc.date.accessioned2007-01-03T08:38:12Z
dc.date.available2007-01-03T08:38:12Z
dc.date.issued2006-11-01
dc.identifier.citationInt J Obes (Lond) 2006, 30(11):1623-31en
dc.identifier.issn0307-0565
dc.identifier.pmid16552400
dc.identifier.doi10.1038/sj.ijo.0803324
dc.identifier.urihttp://hdl.handle.net/10029/6755
dc.description.abstractOBJECTIVE: To examine the relationship between body mass index (BMI) and waist-hip ratio (WHR) with serum levels of insulin-like growth factor-I (IGF-I), and its binding protein (IGFBP)-3. DESIGN: Cross-sectional study on 2139 women participating in a case-control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzyme-linked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3. RESULTS: Adjusted mean serum IGF-I values were lower in women with BMI<22.5 kg/m(2) or BMI>29.2 kg/m(2) compared to women with BMI within this range (P(heterogeneity)<0.0001, P(trend)=0.35). Insulin-like growth factor-I was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (P (trend)=0.005). CONCLUSIONS: Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to non-obese women and inversely related to central adiposity.
dc.format.extent164553 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleBody mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T14:43:18Z
html.description.abstractOBJECTIVE: To examine the relationship between body mass index (BMI) and waist-hip ratio (WHR) with serum levels of insulin-like growth factor-I (IGF-I), and its binding protein (IGFBP)-3. DESIGN: Cross-sectional study on 2139 women participating in a case-control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzyme-linked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3. RESULTS: Adjusted mean serum IGF-I values were lower in women with BMI<22.5 kg/m(2) or BMI>29.2 kg/m(2) compared to women with BMI within this range (P(heterogeneity)<0.0001, P(trend)=0.35). Insulin-like growth factor-I was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (P (trend)=0.005). CONCLUSIONS: Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to non-obese women and inversely related to central adiposity.


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