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dc.contributor.authorPischon, Tobias
dc.contributor.authorLahmann, Petra H
dc.contributor.authorBoeing, Heiner
dc.contributor.authorFriedenreich, Christine
dc.contributor.authorNorat, Teresa
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHalkjaer, Jytte
dc.contributor.authorOvervad, Kim
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorGuernec, Gregory
dc.contributor.authorBergmann, Manuela M
dc.contributor.authorLinseisen, Jakob
dc.contributor.authorBecker, Nikolaus
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorSieri, Sabina
dc.contributor.authorPalli, Domenico
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPeeters, Petra H M
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorBoshuizen, Hendriek C
dc.contributor.authorGuelpen, Bethany van
dc.contributor.authorPalmqvist, Richard
dc.contributor.authorBerglund, Göran
dc.contributor.authorGonzález, Carlos Alberto
dc.contributor.authorDorronsoro Iraeta, Miren
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorNavarro, Carmen A
dc.contributor.authorMartínez-García, Carmen
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorRoddam, Andrew
dc.contributor.authorAllen, Naomi E
dc.contributor.authorBingham, Sheila A
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorFerrari, Pietro
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorSlimani, Nadia
dc.contributor.authorRiboli, Elio
dc.date.accessioned2007-01-02T14:19:20Z
dc.date.available2007-01-02T14:19:20Z
dc.date.issued2006-07-05
dc.identifier.citationJ. Natl. Cancer Inst. 2006, 98(13):920-31en
dc.identifier.issn1460-2105
dc.identifier.pmid16818856
dc.identifier.doi10.1093/jnci/djj246
dc.identifier.urihttp://hdl.handle.net/10029/6736
dc.description.abstractBACKGROUND: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. METHODS: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women who were free of cancer at baseline from nine countries of the European Prospective Investigation Into Cancer and Nutrition. All statistical tests were two-sided. RESULTS: During 6.1 years of follow-up, we identified 984 and 586 patients with colon and rectal cancer, respectively. Body weight and BMI were statistically significantly associated with colon cancer risk in men (highest versus lowest quintile of BMI, relative risk [RR] = 1.55, 95% confidence interval [CI] = 1.12 to 2.15; P(trend) = .006) but not in women. In contrast, comparisons of the highest to the lowest quintile showed that several anthropometric measures, including waist circumference (men, RR = 1.39, 95% CI = 1.01 to 1.93; P(trend) = .001; women, RR = 1.48, 95% CI = 1.08 to 2.03; P(trend) = .008), waist-to-hip ratio (WHR; men, RR = 1.51, 95% CI = 1.06 to 2.15; P(trend) = .006; women, RR = 1.52, 95% CI = 1.12 to 2.05; P(trend) = .002), and height (men, RR = 1.40, 95% CI = 0.99 to 1.98; P(trend) = .04; women, RR = 1.79, 95% CI = 1.30 to 2.46; P(trend)<.001) were related to colon cancer risk in both sexes. The estimated absolute risk of developing colon cancer within 5 years was 203 and 131 cases per 100,000 men and 129 and 86 cases per 100,000 women in the highest and lowest quintiles of WHR, respectively. Upon further stratification, no association of waist circumference and WHR with risk of colon cancer was observed among postmenopausal women who used HRT. None of the anthropometric measures was statistically significantly related to rectal cancer. CONCLUSIONS: Waist circumference and WHR, indicators of abdominal obesity, were strongly associated with colon cancer risk in men and women in this population. The association of abdominal obesity with colon cancer risk may vary depending on HRT use in postmenopausal women; however, these findings require confirmation in future studies.
dc.format.extent253270 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleBody size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC).en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T14:42:43Z
html.description.abstractBACKGROUND: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. METHODS: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women who were free of cancer at baseline from nine countries of the European Prospective Investigation Into Cancer and Nutrition. All statistical tests were two-sided. RESULTS: During 6.1 years of follow-up, we identified 984 and 586 patients with colon and rectal cancer, respectively. Body weight and BMI were statistically significantly associated with colon cancer risk in men (highest versus lowest quintile of BMI, relative risk [RR] = 1.55, 95% confidence interval [CI] = 1.12 to 2.15; P(trend) = .006) but not in women. In contrast, comparisons of the highest to the lowest quintile showed that several anthropometric measures, including waist circumference (men, RR = 1.39, 95% CI = 1.01 to 1.93; P(trend) = .001; women, RR = 1.48, 95% CI = 1.08 to 2.03; P(trend) = .008), waist-to-hip ratio (WHR; men, RR = 1.51, 95% CI = 1.06 to 2.15; P(trend) = .006; women, RR = 1.52, 95% CI = 1.12 to 2.05; P(trend) = .002), and height (men, RR = 1.40, 95% CI = 0.99 to 1.98; P(trend) = .04; women, RR = 1.79, 95% CI = 1.30 to 2.46; P(trend)<.001) were related to colon cancer risk in both sexes. The estimated absolute risk of developing colon cancer within 5 years was 203 and 131 cases per 100,000 men and 129 and 86 cases per 100,000 women in the highest and lowest quintiles of WHR, respectively. Upon further stratification, no association of waist circumference and WHR with risk of colon cancer was observed among postmenopausal women who used HRT. None of the anthropometric measures was statistically significantly related to rectal cancer. CONCLUSIONS: Waist circumference and WHR, indicators of abdominal obesity, were strongly associated with colon cancer risk in men and women in this population. The association of abdominal obesity with colon cancer risk may vary depending on HRT use in postmenopausal women; however, these findings require confirmation in future studies.


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