Novel mumps virus epitopes reveal robust cytotoxic T cell responses after natural infection but not after vaccination.
|dc.contributor.author||Emmelot, Maarten E|
|dc.contributor.author||Meiring, Hugo D|
|dc.contributor.author||van Els, Cécile A C M|
|dc.contributor.author||de Wit, Jelle|
|dc.description.abstract||Mumps is nowadays re-emerging despite vaccination. The contribution of T cell immunity to protection against mumps has not been clearly defined. Previously, we described a set of 41 peptides that were eluted from human leukocyte antigen (HLA) class I molecules of mumps virus (MuV)-infected cells. Here, we confirmed immunogenicity of five novel HLA-B*07:02- and HLA-A*01:01-restricted MuV T cell epitopes from this set of peptides. High frequencies of T cells against these five MuV epitopes could be detected ex vivo in all tested mumps patients. Moreover, these epitope-specific T cells derived from mumps patients displayed strong cytotoxic activity. In contrast, only marginal T cell responses against these novel MuV epitopes could be detected in recently vaccinated persons, corroborating earlier findings. Identifying which MuV epitopes are dominantly targeted in the mumps-specific CD8+ T- response is an important step towards better understanding in the discrepancies between natural infection or vaccination-induced cell-mediated immune protection.||en_US|
|dc.title||Novel mumps virus epitopes reveal robust cytotoxic T cell responses after natural infection but not after vaccination.||en_US|
|dc.identifier.journal||Sci Rep 2021; 11(1):13664||en_US|