Novel mumps virus epitopes reveal robust cytotoxic T cell responses after natural infection but not after vaccination.
dc.contributor.author | Kaaijk, Patricia | |
dc.contributor.author | Emmelot, Maarten E | |
dc.contributor.author | Meiring, Hugo D | |
dc.contributor.author | van Els, Cécile A C M | |
dc.contributor.author | de Wit, Jelle | |
dc.date.accessioned | 2021-07-15T20:19:46Z | |
dc.date.available | 2021-07-15T20:19:46Z | |
dc.date.issued | 2021-07-01 | |
dc.identifier.pmid | 34211021 | |
dc.identifier.doi | 10.1038/s41598-021-92926-1 | |
dc.identifier.uri | http://hdl.handle.net/10029/625100 | |
dc.description.abstract | Mumps is nowadays re-emerging despite vaccination. The contribution of T cell immunity to protection against mumps has not been clearly defined. Previously, we described a set of 41 peptides that were eluted from human leukocyte antigen (HLA) class I molecules of mumps virus (MuV)-infected cells. Here, we confirmed immunogenicity of five novel HLA-B*07:02- and HLA-A*01:01-restricted MuV T cell epitopes from this set of peptides. High frequencies of T cells against these five MuV epitopes could be detected ex vivo in all tested mumps patients. Moreover, these epitope-specific T cells derived from mumps patients displayed strong cytotoxic activity. In contrast, only marginal T cell responses against these novel MuV epitopes could be detected in recently vaccinated persons, corroborating earlier findings. Identifying which MuV epitopes are dominantly targeted in the mumps-specific CD8+ T- response is an important step towards better understanding in the discrepancies between natural infection or vaccination-induced cell-mediated immune protection. | en_US |
dc.language.iso | en | en_US |
dc.title | Novel mumps virus epitopes reveal robust cytotoxic T cell responses after natural infection but not after vaccination. | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 2045-2322 | |
dc.identifier.journal | Sci Rep 2021; 11(1):13664 | en_US |
dc.source.journaltitle | Scientific reports | |
dc.source.volume | 11 | |
dc.source.issue | 1 | |
dc.source.beginpage | 13664 | |
dc.source.endpage | ||
dc.source.country | England |