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dc.contributor.authorKaaijk, Patricia
dc.contributor.authorEmmelot, Maarten E
dc.contributor.authorKerkhof, Jeroen
dc.contributor.authorvan Els, Cécile A C M
dc.contributor.authorMeiring, Hugo D
dc.contributor.authorde Wit, Jelle
dc.contributor.authorBodewes, Rogier
dc.date.accessioned2021-07-15T19:44:11Z
dc.date.available2021-07-15T19:44:11Z
dc.date.issued2021-06-25
dc.identifier.issn2076-393X
dc.identifier.pmid34202193
dc.identifier.doi10.3390/vaccines9070699
dc.identifier.urihttp://hdl.handle.net/10029/625093
dc.description.abstractNowadays, mumps is re-emerging in highly vaccinated populations. Waning of vaccine-induced immunity plays a role, but antigenic differences between vaccine and mumps outbreak strains could also contribute to reduced vaccine effectiveness. CD8+ T cells play a critical role in immunity to viruses. However, limited data are available about sequence variability in CD8+ T cell epitope regions of mumps virus (MuV) proteins. Recently, the first set of naturally presented human leukocyte antigen Class I (HLA-I) epitopes of MuV was identified by us. In the present study, sequences of 40 CD8+ T cell epitope candidates, including previously and newly identified, obtained from Jeryl-Lynn mumps vaccine strains were compared with genomes from 462 circulating MuV strains. In 31 epitope candidates (78%) amino acid differences were detected, and in 17 (43%) of the epitope candidates the corresponding sequences in wild-type strains had reduced predicted HLA-I-binding compared to the vaccine strains. These findings suggest that vaccinated persons may have reduced T cell immunity to circulating mumps viruses due to antigenic differences.en_US
dc.language.isoenen_US
dc.subjectHLA-Ien_US
dc.subjectJeryl–Lynn mumps vaccineen_US
dc.subjectT cell cross-reactivityen_US
dc.subjectT cell epitopesen_US
dc.subjectT cell responseen_US
dc.subjectantigenic variationen_US
dc.subjectcytotoxic CD8+ T cellsen_US
dc.subjectimmunoinformaticsen_US
dc.subjectmumps virusen_US
dc.subjectwild-type strainsen_US
dc.titleGenetic Analysis Reveals Differences in CD8 T Cell Epitope Regions That May Impact Cross-Reactivity of Vaccine-Induced T Cells against Wild-Type Mumps Viruses.en_US
dc.typeArticleen_US
dc.identifier.journalVaccines 2021; 9(7):699en_US
dc.source.journaltitleVaccines
dc.source.volume9
dc.source.issue7
dc.source.countrySwitzerland


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