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dc.contributor.authorJukema, Jelmer B
dc.contributor.authorHoenderboom, Bernice M
dc.contributor.authorvan Benthem, Birgit H B
dc.contributor.authorvan der Sande, Marianne A B
dc.contributor.authorde Vries, Henry J C
dc.contributor.authorHoebe, Christian J P A
dc.contributor.authorDukers-Muijrers, Nicole H T M
dc.contributor.authorBax, Caroline J
dc.contributor.authorMorré, Servaas A
dc.contributor.authorOuburg, Sander
dc.date.accessioned2021-01-25T10:16:57Z
dc.date.available2021-01-25T10:16:57Z
dc.date.issued2021-01-07
dc.identifier.issn2076-0817
dc.identifier.pmid33430411
dc.identifier.doi10.3390/pathogens10010048
dc.identifier.urihttp://hdl.handle.net/10029/624649
dc.description.abstractClear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPs might be used as a genetic component in a tubal-pathology predicting algorithm. Our aim was to confirm the role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women from five cohorts were genotyped and analyzed for TLR2 + 2477 G > A, NOD1 + 32656 T -> GG, CXCR5 + 10950 T > C, and IL10 - 1082 A > G. Results confirmed that NOD1 + 32656 T ->GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1-3.4, p = 0.02), but we did not observe an association with late complications. IL10 - 1082 A > G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR = 2.8, 95%CI: 1.1-7.1, p = 0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs' role in the susceptibility and severity of a CT infection.en_US
dc.language.isoenen_US
dc.subjectChlamydia trachomatisen_US
dc.subjectSNPen_US
dc.subjectseverityen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectsusceptibilityen_US
dc.titleCan Previous Associations of Single Nucleotide Polymorphisms in the , , , and Genes in the Susceptibility to and Severity of Infections Be Confirmed?en_US
dc.typeArticleen_US
dc.identifier.journalPathogens 2021; 10(1):e48en_US
dc.source.journaltitlePathogens (Basel, Switzerland)
dc.source.volume10
dc.source.issue1
dc.source.countryNetherlands
dc.source.countrySwitzerland


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