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dc.contributor.authorLuo, Zhen
dc.contributor.authorLi, Zhuoqing
dc.contributor.authorXie, Zhe
dc.contributor.authorSokolova, Inna M
dc.contributor.authorSong, Lan
dc.contributor.authorPeijnenburg, Willie J G M
dc.contributor.authorHu, Menghong
dc.contributor.authorWang, Youji
dc.date.accessioned2020-08-30T15:02:50Z
dc.date.available2020-08-30T15:02:50Z
dc.date.issued2020-08-06
dc.identifier.issn1613-6829
dc.identifier.pmid32761797
dc.identifier.doi10.1002/smll.202002019
dc.identifier.urihttp://hdl.handle.net/10029/624338
dc.description.abstractTitanium dioxide nanoparticles (nano-TiO2 ) are widely used in consumer products, raising environmental and health concerns. An overview of the toxic effects of nano-TiO2 on human and environmental health is provided. A meta-analysis is conducted to analyze the toxicity of nano-TiO2 to the liver, circulatory system, and DNA in humans. To assess the environmental impacts of nano-TiO2 , aquatic environments that receive high nano-TiO2 inputs are focused on, and the toxicity of nano-TiO2 to aquatic organisms is discussed with regard to the present and predicted environmental concentrations. Genotoxicity, damage to membranes, inflammation and oxidative stress emerge as the main mechanisms of nano-TiO2 toxicity. Furthermore, nano-TiO2 can bind with free radicals and signal molecules, and interfere with the biochemical reactions on plasmalemma. At the higher organizational level, nano-TiO2 toxicity is manifested as the negative effects on fitness-related organismal traits including feeding, reproduction and immunity in aquatic organisms. Bibliometric analysis reveals two major research hot spots including the molecular mechanisms of toxicity of nano-TiO2 and the combined effects of nano-TiO2 and other environmental factors such as light and pH. The possible measures to reduce the harmful effects of nano-TiO2 on humans and non-target organisms has emerged as an underexplored topic requiring further investigation.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbibliometric analysisen_US
dc.subjectecotoxicityen_US
dc.subjecthealthen_US
dc.subjectmeta-analysisen_US
dc.subjecttitanium dioxide nanoparticlesen_US
dc.subjecttoxicityen_US
dc.titleRethinking Nano-TiO Safety: Overview of Toxic Effects in Humans and Aquatic Animals.en_US
dc.typeArticleen_US
dc.identifier.journalNano-micro Small 2020; 16(36):e2002019en_US
dc.source.journaltitleSmall (Weinheim an der Bergstrasse, Germany)


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