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dc.contributor.authorOude Munnink, Bas B
dc.contributor.authorNieuwenhuijse, David F
dc.contributor.authorStein, Mart
dc.contributor.authorO'Toole, Áine
dc.contributor.authorHaverkate, Manon
dc.contributor.authorMollers, Madelief
dc.contributor.authorKamga, Sandra K
dc.contributor.authorSchapendonk, Claudia
dc.contributor.authorPronk, Mark
dc.contributor.authorLexmond, Pascal
dc.contributor.authorvan der Linden, Anne
dc.contributor.authorBestebroer, Theo
dc.contributor.authorChestakova, Irina
dc.contributor.authorOvermars, Ronald J
dc.contributor.authorvan Nieuwkoop, Stefan
dc.contributor.authorMolenkamp, Richard
dc.contributor.authorvan der Eijk, Annemiek A
dc.contributor.authorGeurtsvanKessel, Corine
dc.contributor.authorVennema, Harry
dc.contributor.authorMeijer, Adam
dc.contributor.authorRambaut, Andrew
dc.contributor.authorvan Dissel, Jaap
dc.contributor.authorSikkema, Reina S
dc.contributor.authorTimen, Aura
dc.contributor.authorKoopmans, Marion
dc.date.accessioned2020-08-14T10:59:41Z
dc.date.available2020-08-14T10:59:41Z
dc.date.issued2020-07-16
dc.identifier.issn1546-170X
dc.identifier.pmid32678356
dc.identifier.doi10.1038/s41591-020-0997-y
dc.identifier.urihttp://hdl.handle.net/10029/624038
dc.description.abstractIn late December 2019, a cluster of cases of pneumonia of unknown etiology were reported linked to a market in Wuhan, China1. The causative agent was identified as the species Severe acute respiratory syndrome-related coronavirus and was named SARS-CoV-2 (ref. 2). By 16 April the virus had spread to 185 different countries, infected over 2,000,000 people and resulted in over 130,000 deaths3. In the Netherlands, the first case of SARS-CoV-2 was notified on 27 February. The outbreak started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, and later also outside, the south of the Netherlands. The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands. We demonstrate how these data were generated and analyzed, and how SARS-CoV-2 whole-genome sequencing, in combination with epidemiological data, was used to inform public health decision-making in the Netherlands.en_US
dc.language.isoenen_US
dc.titleRapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands.en_US
dc.typeArticleen_US
dc.identifier.journalNat Med 2020; 26(9):1405-10en_US
dc.source.journaltitleNature medicine


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