Antibody Specificity Following a Recent Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood.
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Authors
Raeven, René H Mvan der Maas, Larissa
Pennings, Jeroen L A
Fuursted, Kurt
Jørgensen, Charlotte Sværke
van Riet, Elly
Metz, Bernard
Kersten, Gideon F A
Dalby, Tine
Type
ArticleLanguage
en
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Show full item recordTitle
Antibody Specificity Following a Recent Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood.Published in
Front Immunol 2019; 10:1364PMID
31275314ae974a485f413a2113503eed53cd6c53
10.3389/fimmu.2019.01364
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Detection of opsonizing antibodies directed against a recently circulating Bordetella pertussis strain in paired plasma samples from symptomatic and recovered pertussis patients.Hovingh, Elise S; Kuipers, Betsy; Bonačić Marinović, Axel A; Jan Hamstra, Hendrik; Hijdra, Danielle; Mughini Gras, Lapo; van Twillert, Inonge; Jongerius, Ilse; van Els, Cecile A C M; Pinelli, Elena (2018-08-13)Correlates of protection (CoPs) against the highly contagious respiratory disease whooping cough, caused by Bordetella pertussis, remain elusive. Characterizing the antibody response to this pathogen is essential towards identifying potential CoPs. Here, we evaluate levels, avidity and functionality of B. pertussis-specific-antibodies from paired plasma samples derived from symptomatic and recovered pertussis patients, as well as controls. Natural infection is expected to induce protective immunity. IgG levels and avidity to nine B. pertussis antigens were determined using a novel multiplex panel. Furthermore, opsonophagocytosis of a B. pertussis clinical isolate by neutrophils was measured. Findings indicate that following infection, B. pertussis-specific antibody levels of (ex-) pertussis patients waned, while the avidity of antibodies directed against the majority of studied antigens increased. Opsonophagocytosis indices decreased upon recovery, but remained higher than controls. Random forest analysis of all the data revealed that 28% of the opsonophagocytosis index variances could be explained by filamentous hemagglutinin- followed by pertussis toxin-specific antibodies. We propose to further explore which other B. pertussis-specific antibodies can better predict opsonophagocytosis. Moreover, other B. pertussis-specific antibody functions as well as the possible integration of these functions in combination with other immune cell properties should be evaluated towards the identification of CoPs against pertussis.
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Side-effects of pertussis toxin, pertussis vaccines and haemoinfluenza type B vaccinevan Amsterdam JGC; te Biesebeek JD; van de Kuil A; Vleeming W; van der Laan JW; Spruyt B; Wemer J; de Wildt DJ; LEO; LGM (Rijksinstituut voor Volksgezondheid en Milieu RIVM, 1997-04-30)Doel van de studie is de bijwerkingen van vaccins nader te bestuderen ter onderbouwing van voor te stellen richtlijnen. Bedoelde richtlijnen stellen eisen aan het verrichten van pre-klinische veiligheids-farmacologie van vaccins. Dit rapport beschrijft de cardiovasculaire en autonome effecten, die in-vivo worden waargenomen in jonge en volwassen ratten behandeld met hoge doseringen pertussis toxine, cellulair (DKTP-vaccin) en acellulair pertussis vaccin en Haemoinfluenza type b vaccin. Deze effecten refereren wellicht aan de collaps (flauwvallen) van de kinderen tijdens of vlak na de vaccinatie met kinkhoest vaccin. De belangrijkste effecten, die door pertussis toxine, DKTP and acellulair pertussis vaccin worden geinduceerd zijn hypotensie, tachycardie en remming van de adrenerge en cholinerge responsen. Volwassen ratten blijken gevoeliger voor deze stoffen te zijn dan jonge ratten en de respons hangt af van de toedieningsroute. Er worden geen effecten waargenomen in ratten, die behandeld zijn met DTP (deze mist de pertussis component) en Haemoinfluenza vaccin. Het wordt aanbevolen om de veiligheid van vaccins vast te stellen via bepaling van de cardiovasculaire en autonome bijwerkingen in volwassen ratten, die 3-4 keer met hoge dosis (20x de klinische dosering) en een middelhoge dosis zijn behandeld. Ten einde de klinische relevantie van de resultaten van het veiligheidsonderzoek afdoende vast te kunnen stellen, dient tot slot nog onderzocht te worden of herhaald i.m. toedienen van middelhoge dosis vaccins aan volwassen ratten dezelfde effecten induceert als waargenomen na i.v. toediening.<br>
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Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination.van Schuppen, Evi; Fröberg, Janeri; Venkatasubramanian, Prashanna Balaji; Versteegen, Pauline; de Graaf, Hans; Holubová, Jana; Gillard, Joshua; van Gageldonk, Pieter G M; Joosten, Irma; de Groot, Ronald; et al. (2022-12-02)