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dc.contributor.authorLuyten, Jeroen
dc.contributor.authorKessels, Roselinde
dc.contributor.authorAtkins, Katherine E
dc.contributor.authorJit, Mark
dc.contributor.authorvan Hoek, Albert Jan
dc.date.accessioned2019-04-08T07:20:13Z
dc.date.available2019-04-08T07:20:13Z
dc.date.issued2019-03-20
dc.identifier.issn1873-5347
dc.identifier.pmid30925392
dc.identifier.doi10.1016/j.socscimed.2019.03.025
dc.identifier.urihttp://hdl.handle.net/10029/622999
dc.description.abstractVaccination programs generate direct protection, herd protection and, occasionally, side effects, distributed over different age groups. This study elicits the general public's view on how to balance these outcomes in funding decisions for vaccines. We performed an optimal design discrete choice experiment with partial profiles in a representative sample (N = 1499) of the population in the United Kingdom in November 2016. Using a panel mixed logit model, we quantified, for four different types of infectious disease, the importance of a person's age during disease, how disease was prevented-via direct vaccine protection or herd protection-and whether the vaccine induced side effects. Our study shows clear patterns in how the public values vaccination programs. These diverge from the assumptions made in public health and cost-effectiveness models that inform decision-making. We found that side effects and infections in newborns and children were of primary importance to the perceived value of a vaccination program. Averting side effects was, in any age group, weighted three times as important as preventing an identical natural infection in a child whereas the latter was weighted six times as important as preventing the same infection in elderly aged 65-75 years. These findings were independent of the length or severity of the disease, and were robust across respondents' backgrounds. We summarize these patterns in a set of preference weights that can be incorporated into future models. Although the normative significance of these weights remains a matter open for debate, our study can, hopefully, contribute to the evaluation of vaccination programs beyond cost-effectiveness.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAgeen_US
dc.subjectCost-effectiveness analysisen_US
dc.subjectDecision makingen_US
dc.subjectEquityen_US
dc.subjectHerd immunityen_US
dc.subjectPriority-settingen_US
dc.subjectSide effectsen_US
dc.subjectUnited Kingdomen_US
dc.titleQuantifying the public's view on social value judgments in vaccine decision-making: A discrete choice experiment.en_US
dc.typeArticleen_US
dc.identifier.journalSoc Sci Medf 2019; 228:181-93en_US
dc.source.journaltitleSocial science & medicine (1982)


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