Differences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins.
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Authors
Gouma, SigridVermeire, Tessa
Van Gucht, Steven
Martens, Lennart
Hutse, Veronik
Cremer, Jeroen
Rota, Paul A
Leroux-Roels, Geert
Koopmans, Marion
Binnendijk, Rob van
Vandermarliere, Elien
Type
ArticleLanguage
en
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Differences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins.Published in
Sci Rep 2018; 8(1):13337Publiekssamenvatting
The surface proteins of the mumps virus, the fusion protein (F) and haemagglutinin-neuraminidase (HN), are key factors in mumps pathogenesis and are important targets for the immune response during mumps virus infection. We compared the predicted amino acid sequences of the F and HN genes from Dutch mumps virus samples from the pre-vaccine era (1957-1982) with mumps virus genotype G strains (from 2004 onwards). Genotype G is the most frequently detected mumps genotype in recent outbreaks in vaccinated communities, especially in Western Europe, the USA and Japan. Amino acid differences between the Jeryl Lynn vaccine strains (genotype A) and genotype G strains were predominantly located in known B-cell epitopes and in N-linked glycosylation sites on the HN protein. There were eight variable amino acid positions specific to genotype A or genotype G sequences in five known B-cell epitopes of the HN protein. These differences may account for the reported antigenic differences between Jeryl Lynn and genotype G strains. We also found amino acid differences in and near sites on the HN protein that have been reported to play a role in mumps virus pathogenesis. These differences may contribute to the occurrence of genotype G outbreaks in vaccinated communities.PMID
30190529ae974a485f413a2113503eed53cd6c53
10.1038/s41598-018-31630-z
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Except where otherwise noted, this item's license is described as Archived with thanks to Scientific reports
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