Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsBradbury, Kathryn E
Appleby, Paul N
Tipper, Sarah J
Travis, Ruth C
Allen, Naomi E
Turzanski Fortner, Renée
La Vecchia, Carlo
Stratigos, Alexander J
Peeters, Petra H
Veierød, Marit B
Huerta, José María
Gunter, Marc J
Tsilidis, Konstantinos K
Key, Timothy J
MetadataShow full item record
TitleCirculating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition.
Published inInt J Cancer 2019; 144(5):957-66
PubliekssamenvattingInsulin-like growth factor (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1221 melanoma cases and 1221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity, and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth=0.93 (95% confidence interval (CI): 0.71 to 1.22)). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by sex, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma. This article is protected by copyright. All rights reserved.
- Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition.
- Authors: Lin C, Travis RC, Appleby PN, Tipper S, Weiderpass E, Chang-Claude J, Gram IT, Kaaks R, Kiemeney LA, Ljungberg B, Tumino R, Tjønneland A, Roswall N, Overvad K, Boutron-Ruault MC, Manciniveri FR, Severi G, Trichopoulou A, Masala G, Sacerdote C, Agnoli C, Panico S, Bueno-de-Mesquita B, Peeters PH, Salamanca-Fernández E, Chirlaque MD, Ardanaz E, Dorronsoro M, Menéndez V, Luján-Barroso L, Liedberg F, Freisling H, Gunter M, Aune D, Cross AJ, Riboli E, Key TJ, Perez-Cornago A
- Issue date: 2018 Nov 15
- Insulin-like growth factor-I concentration and risk of prostate cancer: results from the European Prospective Investigation into Cancer and Nutrition.
- Authors: Price AJ, Allen NE, Appleby PN, Crowe FL, Travis RC, Tipper SJ, Overvad K, Grønbæk H, Tjønneland A, Johnsen NF, Rinaldi S, Kaaks R, Lukanova A, Boeing H, Aleksandrova K, Trichopoulou A, Trichopoulos D, Andarakis G, Palli D, Krogh V, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Argüelles MV, Sánchez MJ, Chirlaque MD, Barricarte A, Larrañaga N, González CA, Stattin P, Johansson M, Khaw KT, Wareham N, Gunter M, Riboli E, Key T
- Issue date: 2012 Sep
- Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition.
- Authors: Perez-Cornago A, Appleby PN, Tipper S, Key TJ, Allen NE, Nieters A, Vermeulen R, Roulland S, Casabonne D, Kaaks R, Fortner RT, Boeing H, Trichopoulou A, La Vecchia C, Klinaki E, Hansen L, Tjønneland A, Bonnet F, Fagherazzi G, Boutron-Ruault MC, Pala V, Masala G, Sacerdote C, Peeters PH, Bueno-de-Mesquita HB, Weiderpass E, Dorronsoro M, Quirós JR, Barricarte A, Gavrila D, Agudo A, Borgquist S, Rosendahl AH, Melin B, Wareham N, Khaw KT, Gunter M, Riboli E, Vineis P, Travis RC
- Issue date: 2017 Mar 1
- Insulin-like growth factor-i and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition.
- Authors: Schmidt JA, Allen NE, Almquist M, Franceschi S, Rinaldi S, Tipper SJ, Tsilidis KK, Weiderpass E, Overvad K, Tjønneland A, Boutron-Ruault MC, Dossus L, Mesrine S, Kaaks R, Lukanova A, Boeing H, Lagiou P, Trichopoulos D, Trichopoulou A, Palli D, Krogh V, Panico S, Tumino R, Zanetti R, Bueno-de-Mesquita HB, Peeters PH, Lund E, Menéndez V, Agudo A, Sánchez MJ, Chirlaque MD, Ardanaz E, Larrañaga N, Hennings J, Sandström M, Khaw KT, Wareham N, Romieu I, Gunter MJ, Riboli E, Key TJ, Travis RC
- Issue date: 2014 Jun
- IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).
- Authors: Rinaldi S, Peeters PH, Berrino F, Dossus L, Biessy C, Olsen A, Tjonneland A, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, Téhard B, Nagel G, Linseisen J, Boeing H, Lahmann PH, Trichopoulou A, Trichopoulos D, Koliva M, Palli D, Panico S, Tumino R, Sacerdote C, van Gils CH, van Noord P, Grobbee DE, Bueno-de-Mesquita HB, Gonzalez CA, Agudo A, Chirlaque MD, Barricarte A, Larrañaga N, Quiros JR, Bingham S, Khaw KT, Key T, Allen NE, Lukanova A, Slimani N, Saracci R, Riboli E, Kaaks R
- Issue date: 2006 Jun