Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
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Authors
Buelow, ElenaBello Gonzalez, Teresita dJ
Fuentes, Susana
de Steenhuijsen Piters, Wouter AA
Lahti, Leo
Bayjanov, Jumamurat R
Majoor, Eline AM
Braat, Johanna C
van Mourik, Maaike S M
Oostdijk, Evelien AN
Willems, Rob JL
Bonten, Marc J M
van Passel, Mark WJ
Smidt, Hauke
van Schaik, Willem
Type
ArticleLanguage
en
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Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.Published in
Microbiome 2017, 5(1):188Publiekssamenvatting
The gut microbiota is a reservoir of opportunistic pathogens that can cause life-threatening infections in critically ill patients during their stay in an intensive care unit (ICU). To suppress gut colonization with opportunistic pathogens, a prophylactic antibiotic regimen, termed "selective decontamination of the digestive tract" (SDD), is used in some countries where it improves clinical outcome in ICU patients. Yet, the impact of ICU hospitalization and SDD on the gut microbiota remains largely unknown. Here, we characterize the composition of the gut microbiota and its antimicrobial resistance genes ("the resistome") of ICU patients during SDD and of healthy subjects.PMID
28803549ae974a485f413a2113503eed53cd6c53
10.1186/s40168-017-0309-z
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