Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia.
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Authors
Sengstake, SarahBergval, Indra L
Schuitema, Anja R
de Beer, Jessica L
Phelan, Jody
de Zwaan, Rina
Clark, Taane G
van Soolingen, Dick
Anthony, Richard M
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ArticleLanguage
en
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Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia.Published in
BMC Infect Dis 2017, 17(1):491Publiekssamenvatting
The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies. A new regimen to treat MDR-TB that includes pyrazinamide (PZA) is currently being evaluated and PZA resistance status will largely influence the success of current and future treatment strategies. PZA susceptibility testing was not routinely performed at the National Reference Laboratory (NRL) in Tbilisi between 2010 and September 2015. We here provide a first insight into the prevalence of PZA resistant TB in this region.PMID
28697808ae974a485f413a2113503eed53cd6c53
10.1186/s12879-017-2594-3
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