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dc.contributor.authorGadroen, Kartini
dc.contributor.authorKemmeren, Jeanet M
dc.contributor.authorBruijning-Verhagen, Patricia Cj
dc.contributor.authorStraus, Sabine Mjm
dc.contributor.authorWeibel, Daniel
dc.contributor.authorde Melker, Hester E
dc.contributor.authorSturkenboom, Miriam Cjm
dc.date.accessioned2018-01-02T13:11:50Z
dc.date.available2018-01-02T13:11:50Z
dc.date.issued2017-06-22
dc.identifier.citationBaseline incidence of intussusception in early childhood before rotavirus vaccine introduction, the Netherlands, January 2008 to December 2012. 2017, 22 (25) Euro Surveill.en
dc.identifier.issn1560-7917
dc.identifier.pmid28662763
dc.identifier.doi10.2807/1560-7917.ES.2017.22.25.30556
dc.identifier.urihttp://hdl.handle.net/10029/620958
dc.description.abstractIntussusception is a rare, potentially life-threatening condition in early childhood. It gained attention due to an unexpected association with the first rotavirus vaccine, RotaShield, which was subsequently withdrawn from the market. Across Europe, broad variations in intussusception incidence rates have been reported. This study provides a first estimate of intussusception incidence in young children in the Netherlands from 1 January 2008 to 31 December 2012, which could be used for future rotavirus safety monitoring. Our estimates are based on two different sources: electronic medical records from the primary healthcare database (IPCI), as well as administrative data from the Dutch hospital register (LBZ). The results from our study indicate a low rate of intussusception. Overall incidence rate in children < 36 months of age was 21.2 per 100,000 person-years (95% confidence interval (CI): 12.5-34.3) based on primary healthcare data and 22.6 per 100,000 person-years (95% CI: 20.9-24.4) based on hospital administrative data. The estimates suggest the upper and lower bound of the expected number of cases.
dc.language.isoenen
dc.rightsArchived with thanks to Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletinen
dc.subject.meshAge Distribution
dc.subject.meshChild, Preschool
dc.subject.meshElectronic Health Records
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshIntussusception
dc.subject.meshMale
dc.subject.meshNetherlands
dc.subject.meshPrimary Health Care
dc.subject.meshRetrospective Studies
dc.subject.meshRotavirus Vaccines
dc.titleBaseline incidence of intussusception in early childhood before rotavirus vaccine introduction, the Netherlands, January 2008 to December 2012.en
dc.typeArticleen
dc.identifier.journalEuro Surveill 2017, 22(25):pii.30556en
html.description.abstractIntussusception is a rare, potentially life-threatening condition in early childhood. It gained attention due to an unexpected association with the first rotavirus vaccine, RotaShield, which was subsequently withdrawn from the market. Across Europe, broad variations in intussusception incidence rates have been reported. This study provides a first estimate of intussusception incidence in young children in the Netherlands from 1 January 2008 to 31 December 2012, which could be used for future rotavirus safety monitoring. Our estimates are based on two different sources: electronic medical records from the primary healthcare database (IPCI), as well as administrative data from the Dutch hospital register (LBZ). The results from our study indicate a low rate of intussusception. Overall incidence rate in children < 36 months of age was 21.2 per 100,000 person-years (95% confidence interval (CI): 12.5-34.3) based on primary healthcare data and 22.6 per 100,000 person-years (95% CI: 20.9-24.4) based on hospital administrative data. The estimates suggest the upper and lower bound of the expected number of cases.


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