Vaccinaties in het eerste levensjaar en gerapporteerde allergische aandoeningen bij kinderen van 8-12 jaar

Abstract

Evidence for the relationship between the diphtheria tetanus pertussis (DTP) vaccination and allergic disorders is inconclusive, because the available studies that constitute the evidence are liable to confounding by indication. Further the Haemophilus influenzae type b (Hib) vaccination was added recently to most existing vaccination programmes and therefore no conclusive data on the relationship with allergic disorders are yet available. Objective of the study was to assess the relationship between vaccinations in the first year of life and reported allergic disorders at primary school age. We conducted a cross sectional study in 1875 children attending Orthodox Reformed (Protestant) primary schools in the Netherlands. The parents returned questionnaires with data on vaccination status, allergic symptoms and lifetime allergic disorders (asthma, hay fever, eczema and food allergy), and possible confounders. In the diphtheria tetanus pertussis (inactivated) poliomyelitis (DTP-IPV) vaccinated group Hib vaccinated and Hib unvaccinated children were compared as to allergic disorders. No clinically or statistically significant differences in the prevalence of asthma, hay fever, eczema and food allergy appeared between vaccinated and unvaccinated groups. The DTP-IPV vaccination and the Hib-vaccination, administered in the first year of life, do not increase the risk of allergic disorders in 8-12 years-old, Dutch children.