• BOREAS - A new MAX-DOAS profile retrieval algorithm for aerosols and trace gases.

      Bosch, T; Rozanov, V; Richter, A; Peters, E; Rozanov, A; Witrrock, F; Merlaud, A; van Berkhout, S (2019-01-14)
    • Borrelia miyamotoi Disease in an Immunocompetent Patient, Western Europe

      Hoornstra, Dieuwertje; Koetsveld, Joris; Sprong, Hein; Platonov, Alexander E.; Hovius, Joppe W. (2018-09)
    • Borrelia miyamotoi infection leads to cross-reactive antibodies to the C6 peptide in mice and men.

      Koetsveld, J; Platonov, A E; Kuleshov, K; Wagemakers, A; Hoornstra, D; Ang, W; Szekeres, S; van Duijvendijk, G L A; Fikrig, E; Embers, M E; et al. (2019-08-09)
    • Both non-smoking youth and smoking adults like sweet and minty e-liquid flavors more than tobacco flavor.

      Krüsemann, Erna J Z; van Tiel, Loes; Pennings, Jeroen L A; Vaessen, Wim; de Graaf, Kees; Talhout, Reinskje; Boesveldt, Sanne (2021-03-04)
    • Brain stem and cerebellar hyperintense lesions in migraine.

      Kruit, Mark C; Launer, Lenore J; Ferrari, Michel D; Buchem, Mark A van (2006-04-01)
      BACKGROUND AND PURPOSE: Migraineurs are at increased risk of cerebellar infarcts and supratentorial white matter lesions. The prevalence, frequency, and distribution of infratentorial hyperintense lesions in migraine are unknown. METHODS: Migraineurs with aura (n=161), without aura (n=134), and controls (n=140) from a population-based sample of adults (30 to 60 years of age) were evaluated with MRI. RESULTS: Infratentorial hyperintensities were identified in 13 of 295 (4.4%) migraineurs and in 1 of 140 (0.7%) controls (P=0.04). Twelve cases had hyperintensities, mostly bilaterally, in the dorsal basis pontis. Those with infratentorial hyperintensities also had supratentorial white matter lesions more often. CONCLUSIONS: We found an increased prevalence of infratentorial (mostly pontine) hyperintensities in migraineurs from the general population. This extends the knowledge about vulnerable brain regions and type of lesions in migraine brains. A hemodynamic ischemic pathogenesis is likely, but further research is needed.
    • Breaking Down Uncertain Risks for Risk Communication: A Conceptual Review of the Environmental Health Literature

      Jansen, Tom; Claassen, Liesbeth; van Poll, Ric; van Kamp, Irene; Timmermans, Daniëlle R. M. (2018-03)
    • Breast milk fatty acids and allergic disease in preschool children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study.

      Wijga, Alet H; Houwelingen, Adriana C van; Kerkhof, Marjan; Tabak, Cora; Jongste, Johan C de; Gerritsen, Jorrit; Boshuizen, Hendriek C; Brunekreef, Bert; Smit, Henriëtte A (2006-02-01)
      BACKGROUND: Better understanding of the association between early life lipid intakes and the development of allergic diseases is needed. OBJECTIVE: We prospectively studied breast milk content of n-6, n-3, and trans fatty acids in relation to allergic symptoms at the ages of 1 and 4 years. METHODS: Fatty acid content was determined in breast milk samples of 265 (158 allergic and 107 nonallergic) mothers of children participating in the Prevention and Incidence of Asthma and Mite Allergy study. Outcome variables studied were parental reported eczema at age 1 year, eczema at age 4 years, asthma at age 4 years, and, in a subgroup of 133 children, sensitization at age 4 years. RESULTS: In children of mothers with allergy, breast milk n-3 long chain polyunsaturated fatty acids and the ratio between n-3 and n-6 long chain polyunsaturated fatty acids were inversely associated with asthma and with persistent symptoms (eczema at age 1 year and eczema at age 4 years and/or asthma at age 4 years), but no associations between breast milk fatty acids and sensitization were observed. In children of mothers with allergy, also trans fatty acids tended to be inversely associated with allergic symptoms. In children of mothers without allergy, no associations between breast milk fatty acids and allergic symptoms were observed, but alpha-linolenic acid (18:3n-3) was positively associated with sensitization. CONCLUSION: In susceptible infants, the risk to develop allergic symptoms, but not the risk of sensitization, was modified by intake of n-3 long chain polyunsaturated fatty acids through breast milk.
    • Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis.

      van Rossem, Lenie; Smit, Henriette A; Armand, Martine; Bernard, Jonathan Y; Bisgaard, Hans; Bønnelykke, Klaus; Bruun, Signe; Heude, Barbara; Husby, Steffen; Kyhl, Henriette B; et al. (2020-06-20)
    • Breastfeeding and cardiometabolic markers at age 12: a population-based birth cohort study.

      Pluymen, L P M; Wijga, A H; Gehring, U; Koppelman, G H; Smit, H A; van Rossem, L (2019-03-18)
      There is growing evidence for a protective effect of breastfeeding against overweight and diabetes. It is less clear though, whether breastfed infants also have a more favorable cardiometabolic profile in childhood. We investigated whether children who were breastfed in infancy had more favorable cardiometabolic markers at 12 years of age than children who were never breastfed and received formula milk instead, and whether associations depended on the duration of breastfeeding. In 1509 participants of the population-based PIAMA birth cohort study, cardiometabolic markers were measured at 12 years of age. Duration of breastfeeding in weeks was assessed through parental questionnaires at 3 months and 1 year of age. Multivariable linear regression analysis was used to investigate associations of breastfeeding (any vs. never breastfeeding and duration of breastfeeding in categories <3 months, 3 to <6 months, and ≥6 months breastfeeding vs. never breastfeeding) with systolic and diastolic blood pressure (SBP and DBP, in Z-scores adjusted for age, sex, and height), total-to-high-density lipoprotein cholesterol (TC/HDLC), glycated hemoglobin (HbA1c, in mmol/mol), body mass index (BMI, in Z-scores adjusted for age and sex) and waist circumference (WC, in cm). Multivariable logistic regression was used to investigate the association of breastfeeding with odds of being overweight. 1288 of 1509 children (85.3%) received any breastmilk in infancy. Breastfed children had a lower SBP Z-score (-0.21 SD (≈ -2.29 mmHg), 95% CI -0.37, -0.06), a lower DBP Z-score (-0.10 SD (≈ -1.19 mmHg), 95% CI -0.20, -0.00), a smaller WC (-1.12 cm, 95% CI -2.20; -0.04), and lower odds of being overweight (OR 0.61, 95% CI 0.38, 0.97) than never breastfed children. These associations were not different between children with shorter and longer duration of breastfeeding. No statistically significant differences in TC/HDLC, HbA1c, and BMI were observed between breastfed and never breastfed children.
    • Bridging communities in the field of nanomedicine.

      Halamoda-Kenzaoui, Blanka; Baconnier, Simon; Bastogne, Thierry; Bazile, Didier; Boisseau, Patrick; Borchard, Gerrit; Borgos, Sven Even; Calzolai, Luigi; Cederbrant, Karin; Di Felice, Gabriella; et al. (2019-08-01)
    • Brochure Elektromagnetische velden en medische hulpmiddelen

      Stam, R (Rijksinstituut voor Volksgezondheid en Milieu, 2019-12-01)
    • Bronopsporing bij een langdurige internationale uitbraak van Salmonella Enteritidis

      Broek I van den; Broek I van den; Dam-Deisz WDC; Voort M van der; Nijs R de; Broek I van den; Broek I van den; Kuiling S; Kerkhof JHCT van den; Leblanc JMJ; et al. (2017-06-19)
    • Brucella Pinnipedialis in grey seals (Halichoerus grypus) and harbor seals (Phoca vitulina) in the Netherlands

      Kroese, Michiel V; Beckers, Lisa; Bisselink, Yvette J W M; Brasseur, Sophie; van Tulden, Peter W; Koene, Miriam G J; Roest, Hendrik I J; Ruuls, Robin C; Backer, Jantien A; IJzer, Jooske; et al. (2018-04-26)
      Brucellosis is a zoonotic disease with terrestrial or marine wildlife animals as potential reservoirs for the disease in livestock and human populations. The primary aim of this study was to assess the presence of Brucella pinnipedialis in marine mammals living along the Dutch coast and to observe a possible correlation between the presence of B. pinnipedialis and accompanying pathology found in infected animals. The overall prevalence of Brucella spp. antibodies in sera from healthy wild grey seals ( Halichoerus grypus; n=11) and harbor seals ( Phoca vitulina; n=40), collected between 2007 and 2013 ranged from 25% to 43%. Additionally, tissue samples of harbor seals collected along the Dutch shores between 2009 and 2012, were tested for the presence of Brucella spp. In total, 77% (30/39) seals were found to be positive for Brucella by IS 711 real-time PCR in one or more tissue samples, including pulmonary nematodes. Viable Brucella was cultured from 40% (12/30) real-time PCR-positive seals, and was isolated from liver, lung, pulmonary lymph node, pulmonary nematode, or spleen, but not from any PCR-negative seals. Tissue samples from lung and pulmonary lymph nodes were the main source of viable Brucella bacteria. All isolates were typed as B. pinnipedialis by multiple-locus variable number of tandem repeats analysis-16 clustering and matrix-assisted laser desorption ionization-time of flight mass spectrometry, and of sequence type ST25 by multilocus sequence typing analysis. No correlation was observed between Brucella infection and pathology. This report displays the isolation and identification of B. pinnipedialis in marine mammals in the Dutch part of the Atlantic Ocean.
    • Building a developmental toxicity ontology.

      Baker, Nancy; Boobis, Alan; Burgoon, Lyle; Carney, Edward; Currie, Richard; Fritsche, Ellen; Knudsen, Thomas; Laffont, Madeleine; Piersma, Aldert H; Poole, Alan; et al. (2018-01-31)
      As more information is generated about modes of action for developmental toxicity and more data are generated using high-throughput and high-content technologies, it is becoming necessary to organize that information. This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e., an ontology) and proposes a method to build one based on knowledge of developmental biology and mode of action/ adverse outcome pathways in developmental toxicity.
    • Building a European exposure science strategy.

      Fantke, Peter; von Goetz, Natalie; Schlüter, Urs; Bessems, Jos; Connolly, Alison; Dudzina, Tatsiana; Ahrens, Andreas; Bridges, Jim; Coggins, Marie A; Conrad, André; et al. (2019-12-02)
    • Building biosecurity for synthetic biology.

      Trump, Benjamin D; Galaitsi, S E; Appleton, Evan; Bleijs, Diederik A; Florin, Marie-Valentine; Gollihar, Jimmy D; Hamilton, R Alexander; Kuiken, Todd; Lentzos, Filippa; Mampuys, Ruth; et al. (2020-07-01)
    • The burden of bacteremic and non-bacteremic Gram-negative infections: a prospective multicenter cohort study in a low-resistance country.

      Deelen, J W Timotëus; Rottier, Wouter C; van Werkhoven, Cornelis H; Woudt, Sjoukje H S; Buiting, Anton G M; Dorigo-Zetsma, J Wendelien; Kluytmans, Jan A J W; van der Linden, Paul D; Thijsen, Steven F T; Vlaminckx, Bart J M; et al. (2020-10-05)
    • Burden of foodborne diseases: think global, act local.

      Pires, SM; Desta, BN; Mughini-Gras, L; Mbaga, BT; Fayemi, OE; Salvador, EM; Gobena, T; Majowicz, SE; Hald, T; Hoejskov, PS; et al. (2021-02-12)
    • The burden of heat-related mortality attributable to recent human-induced climate change.

      Vicedo-Cabrera, AM; Scovronick, N; Sera, F; Roye, D; Schneider, R; Tobias, A; Astrom, C; Houthuijs, D; Ameling, C (2021-06-21)