• 10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis.

      van Berlo, Damiën; Woutersen, Marjolijn; Muller, Andre; Pronk, Marja; Vriend, Jelle; Hakkert, Betty (2022-07-30)
    • 12th IFDC 2017 Special Issue - Evaluation of harmonized EuroFIR documentation for macronutrient values in 26 European food composition databases.

      Westenbrink, S; Kadvan, A; Roe, M; Korousic Seljak, B; Mantur-Vierendeel, A; Finglas, P (2019-07-08)
    • 20 Years of ICF-International Classification of Functioning, Disability and Health: Uses and Applications around the World.

      Leonardi, Matilde; Lee, Haejung; Kostanjsek, Nenad; Fornari, Arianna; Raggi, Alberto; Martinuzzi, Andrea; Yáñez, Manuel; Almborg, Ann-Helene; Fresk, Magdalena; Besstrashnova, Yanina; et al. (2022-09-08)
    • 20-year individual physical activity patterns and related characteristics.

      Loyen, Anne; Wendel-Vos, G C Wanda; Shekoh, Maryam Ismaili; Verschuren, W M Monique; Picavet, H Susan J (2022-03-04)
    • The 2015-2016 influenza epidemic in Beijing, China: Unlike elsewhere, circulation of influenza A(H3N2) with moderate vaccine effectiveness.

      Zhang, Li; Pan, Yang; Hackert, Volker; van der Hoek, Wim; Meijer, Adam; Krafft, Thomas; Yang, Peng; Wang, Quanyi (2018)
      While the 2015-2016 influenza season in the northern hemisphere was dominated by A(H1N1)pdm09 and B/Victoria viruses, in Beijing, China, there was also significant circulation of influenza A(H3N2) virus. In this report we estimate vaccine effectiveness (VE) against influenza A(H3N2) and other circulating viruses, and describe further characteristics of the 2015-2016 influenza season in Beijing.
    • 2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children.

      Kissling, Esther; Valenciano, Marta; Pozo, Francisco; Vilcu, Ana-Maria; Reuss, Annicka; Rizzo, Caterina; Larrauri, Amparo; Horváth, Judit Krisztina; Brytting, Mia; Domegan, Lisa; et al. (2017-11-10)
      During the 2015/16 influenza season in Europe, the cocirculating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine.
    • 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project.

      Rondy, Marc; Larrauri, Amparo; Casado, Itziar; Alfonsi, Valeria; Pitigoi, Daniela; Launay, Odile; Syrjänen, Ritva K; Gefenaite, Giedre; Machado, Ausenda; Vučina, Vesna Višekruna; et al. (2017-07-27)
      We conducted a multicentre test-negative case-control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases.
    • The 2017 Dutch Physical Activity Guidelines.

      Weggemans, Rianne M; Backx, Frank J G; Borghouts, Lars; Chinapaw, Mai; Hopman, Maria T E; Koster, Annemarie; Kremers, Stef; van Loon, Luc J C; May, Anne; Mosterd, Arend; et al. (2018-06-25)
      The objective of this study was to derive evidence-based physical activity guidelines for the general Dutch population.
    • 25 jaar zonkrachtmonitoring door RIVM

      van der Schaaf, M; van Putten, E; van der Reijden, E; den Outer, P; van Dijk, A (2019-05-10)
    • A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats.

      Ven, Leo T M van der; Verhoef, Aart; Kuil, Ton van de; Slob, Wout; Leonards, Pim E G; Visser, Theo J; Hamers, Timo; Herlin, Maria; Håkansson, Helen; Olausson, Hanna; et al. (2006-12-01)
      A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed by daily gavage to HBCD dissolved in corn oil in 8 dose groups with doses ranging between 0 and 200 mg/kg bw per day (mkd). Evaluation consisted of dose-response analysis with calculation of a benchmark dose at the lower 95% one-sided confidence bound (BMDL) at predefined critical effect sizes (CESs) of 10-20%. The most remarkable findings were dose-related effects on the thyroid hormone axis, that is, decreased total thyroxin (TT4, BMDL 55.5 mkd at CES--10%), increased pituitary weight (29 mkd at 10%) and increased immunostaining of TSH in the pituitary, increased thyroid weight (1.6 mkd at 10%), and thyroid follicle cell activation. These effects were restricted to females. Female rats also showed increased absolute liver weights (22.9 mkd at 20%) and induction of T4-glucuronyl transferase (4.1 mkd at 10%), suggesting that aberrant metabolization of T4 triggers feedback activation of the thyroid hormone system. These effects were accompanied by possibly secondary effects, including increased cholesterol (7.4 mkd at 10%), increased tibial bone mineral density (> 49 mkd at 10%), both in females, and decreased splenocyte counts (0.3-6.3 mkd at 20%; only evaluated in males). Overall, female rats appeared to be more sensitive to HBCD than male rats, and an overall BMDL is proposed at 1.6 mkd, based on a 10% increase of the thyroid weight, which was the most sensitive parameter in the sequence of events.
    • 3-Methylmethcathinone (3-MMC) Poisonings: Acute Clinical Toxicity and Time Trend Between 2013 and 2021 in the Netherlands.

      Nugteren-van Lonkhuyzen, Johanna J; Essink, Sharon; Rietjens, Saskia J; Ohana, Dana; de Lange, Dylan W; van Riel, Antoinette J H P; Hondebrink, Laura (2022-06-22)
    • 3D omgevingsmodel Nederland.

      van Loon, R (2020-01-23)
    • A multi-model approach to monitor emissions of CO<sub>2</sub> and CO from an urban–industrial complex

      Super, Ingrid; Denier van der Gon, Hugo A. C.; van der Molen, Michiel K.; Sterk, Hendrika A. M.; Hensen, Arjan; Peters, Wouter (2017-11-09)
      Monitoring urban–industrial emissions is often challenging because observations are scarce and regional atmospheric transport models are too coarse to represent the high spatiotemporal variability in the resulting concentrations. In this paper we apply a new combination of an Eulerian model (Weather Research and Forecast, WRF, with chemistry) and a Gaussian plume model (Operational Priority Substances – OPS). The modelled mixing ratios are compared to observed CO2 and CO mole fractions at four sites along a transect from an urban–industrial complex (Rotterdam, the Netherlands) towards rural conditions for October–December 2014. Urban plumes are well-mixed at our semi-urban location, making this location suited for an integrated emission estimate over the whole study area. The signals at our urban measurement site (with average enhancements of 11 ppm CO2 and 40 ppb CO over the baseline) are highly variable due to the presence of distinct source areas dominated by road traffic/residential heating emissions or industrial activities. This causes different emission signatures that are translated into a large variability in observed ΔCO : ΔCO2 ratios, which can be used to identify dominant source types. We find that WRF-Chem is able to represent synoptic variability in CO2 and CO (e.g. the median CO2 mixing ratio is 9.7 ppm, observed, against 8.8 ppm, modelled), but it fails to reproduce the hourly variability of daytime urban plumes at the urban site (R2 up to 0.05). For the urban site, adding a plume model to the model framework is beneficial to adequately represent plume transport especially from stack emissions. The explained variance in hourly, daytime CO2 enhancements from point source emissions increases from 30 % with WRF-Chem to 52 % with WRF-Chem in combination with the most detailed OPS simulation. The simulated variability in ΔCO :  ΔCO2 ratios decreases drastically from 1.5 to 0.6 ppb ppm−1, which agrees better with the observed standard deviation of 0.4 ppb ppm−1. This is partly due to improved wind fields (increase in R2 of 0.10) but also due to improved point source representation (increase in R2 of 0.05) and dilution (increase in R2 of 0.07). Based on our analysis we conclude that a plume model with detailed and accurate dispersion parameters adds substantially to top–down monitoring of greenhouse gas emissions in urban environments with large point source contributions within a  ∼  10 km radius from the observation sites.
    • Aan de slag met opkomende stoffen in de bodem.

      Wintersen, A; Otte, P; Traas, T (2019-02-12)
    • Aangepast preventiebeleid bij patiënten met hyposplenie of asplenie

      Schreuder, I; Kroon, FP; Peters, EJG; Sanders, EAM; Wildenbeest, JG; Lammers, JAJ (2019-05-06)
    • Aanpassing van de BEL-bemonsteringscriteria.

      Euser, S; Brandsema, P; Ruijs, H (2018-09-18)
    • Aantal tbc-patiënten vergelijkbaar met 2017

      Schimmel, H; Slump, E (2018-09-30)
    • Absence of association between 2019-20 influenza vaccination and COVID-19: Results of the European I-MOVE-COVID-19 primary care project, March-August 2020.

      Kissling, Esther; Hooiveld, Mariëtte; Brytting, Mia; Vilcu, Ana-Maria; de Lange, Marit; Martínez-Baz, Iván; Sigerson, Debbie; Enkirch, Theresa; Belhillil, Sylvie; Meijer, Adam; et al. (2021-01-22)