• Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.

      Frost, Joe N; Tan, Tiong Kit; Abbas, Munawar; Wideman, Sarah K; Bonadonna, Michael; Stoffel, Nicole U; Wray, Katherine; Kronsteiner, Barbara; Smits, Gaby; Campagna, Dean R; et al.
      We used a hepcidin mimetic and several genetic models to examine the effect of low iron availability on T cells in vitro and on immune responses to vaccines and viral infection in mice. We examined humoral immunity in human patients with raised hepcidin and low serum iron caused by mutant TMPRSS6. We tested the effect of iron supplementation on vaccination-induced humoral immunity in piglets, a natural model of iron deficiency.