• A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk.

      Murphy, Neil; Achaintre, David; Zamora-Ros, Raul; Jenab, Mazda; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Savoye, Isabelle; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; et al. (2018-04-26)
      Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95%CI]=0.79-0.93; qvalue =0.01) and homovanillic acid (OR per log2 -value, 1.46, 95%CI=1.16-1.84; qvalue =0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR=0.61, 95%CI=0.41-0.91, ptrend =0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR=1.72, 95%CI=1.17-2.53, ptrend <0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk, of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis. This article is protected by copyright. All rights reserved.
    • Prospective mixture risk assessment and management prioritizations for river catchments with diverse land uses.

      Posthuma, Leo; Brown, Colin; De Zwart, Dick; Diamond, Jerry; Dyer, Scott D; Holmes, Christopher M; Marshall, Stuart; Burton, G Allen (2017-08-28)
      Ecological risk assessment increasingly focuses on risks from chemical mixtures and multiple stressors, because ecosystems are commonly exposed to a plethora of contaminants and non-chemical stressors. To simplify the task of assessing potential mixture effects we explored three land-use related chemical emission scenarios. We applied a tiered methodology to judge the implications of the emissions of chemicals from agricultural practices, domestic discharges and urban run-off in a quantitative model. Results showed land-use dependent mixture exposures, clearly discriminating downstream effects of land uses, with unique chemical 'signatures' regarding composition, concentration and temporal patterns. Associated risks were characterized in relation to the land use scenarios. Comparisons to measured environmental concentrations and predicted impacts showed relatively good similarity. The results suggest that the land uses imply exceedances of regulatory protective Environmental Quality Standards, varying over time in relation to rain events and associated flow and dilution variation. Higher-tier analyses using ecotoxicological effect criteria confirmed that species assemblages may be affected due to exposures exceeding no-effect levels, and that mixture exposure could be associated with predicted species loss under certain situations. The model outcomes can inform various types of prioritization to support risk management, including a ranking across land uses as a whole, a ranking on characteristics of exposure times and frequencies, and various rankings of the relative role of individual chemicals. Though all results are based on in silico assessments, the prospective land-use based approach applied in the present study yields useful insights for simplifying and assessing potential ecological risks of chemical mixtures and can therefore be useful for catchment management decisions. This article is protected by copyright. All rights reserved.
    • Prospects of toxoplasmosis control by cat vaccination.

      Bonačić Marinović, Axel A; Opsteegh, Marieke; Deng, Huifang; Suijkerbuijk, Anita W M; van Gils, Paul F; Van Der Giessen, Joke (2019-12-05)
    • Prosthetic Valve Endocarditis with in a Human European Patient and its Detection in Red Squirrels ().

      von Loewenich, Friederike D; Seckert, Christof; Dauber, Elke; Kik, Marja J L; de Vries, Ankje; Sprong, Hein; Buschmann, Katja; Aardema, Matthew L; Brandstetter, Moritz (2019-10-16)
      Members of the genus Bartonella are fastidious Gram-negative facultative intracellular bacteria that are typically transmitted by arthropod vectors. Several Bartonella spp. have been found to cause culture-negative endocarditis in humans. Here, we report the case of a 75-year old German woman with prosthetic valve endocarditis due to Bartonella washoensis. The infecting agent was characterized by sequencing of six housekeeping genes (16S rRNA, ftsZ, gltA, groEL, ribC, rpoB) applying a multilocus sequence typing (MLST) approach. The 5097 bp of the concatenated housekeeping gene sequence from the patient were 99.0% identical to a B. washoensis strain from a red squirrel (Sciurus vulgaris orientis) from China. 39% (24/62) of red squirrel (S. vulgaris) samples from the Netherlands were positive for the B. washoensis gltA gene variant detected in the patient. This suggests that the red squirrel is the reservoir host for human infection in Europe.
    • Protecting Pyrazinamide, a Priority for Improving Outcomes in Multidrug-Resistant Tuberculosis Treatment.

      Anthony, R M; Cynamon, M; Hoffner, S; Werngren, J; den Hertog, A L; van Soolingen, D (2017-06)
    • Protection of drinking water resources from agricultural pressures: Effectiveness of EU regulations in the context of local realities.

      Wuijts, Susanne; Claessens, Jacqueline; Farrow, Luke; Doody, Donnacha G; Klages, Susanne; Christophoridis, Chris; Cvejić, Rozalija; Glavan, Matjaž; Nesheim, Ingrid; Platjouw, Froukje; et al. (2021-03-15)
    • Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients.

      Jongbloed, Franny; de Bruin, Ron W F; Steeg, Harry Van; Beekhof, Piet; Wackers, Paul; Hesselink, Dennis A; Hoeijmakers, Jan H J; Dollé, Martijn E T; IJzermans, Jan N M (2020-07-11)
    • Protein intake pattern over the day and its association with low total protein intake in Dutch community-dwelling older adults.

      Rooijackers, Teuni H; Ocké, Marga C; Hengeveld, Linda M; Visser, Marjolein; Boer, Jolanda Ma (2020-05-15)
    • Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine.

      van den Biggelaar, Robin H G A; van der Maas, Larissa; Meiring, Hugo D; Pennings, Jeroen L A; van Eden, Willem; Rutten, Victor P M G; Jansen, Christine A (2021-06-16)
    • Providing Access to Urban Green Spaces: A Participatory Benefit-Cost Analysis in Spain.

      García de Jalón, Silvestre; Chiabai, Aline; Mc Tague, Alyvia; Artaza, Naiara; de Ayala, Amaia; Quiroga, Sonia; Kruize, Hanneke; Suárez, Cristina; Bell, Ruth; Taylor, Timothy (2020-04-19)
    • Proximity to agricultural fields as proxy for environmental exposure to pesticides among children: The PIAMA birth cohort.

      Bukalasa, Joseph S; Brunekreef, Bert; Brouwer, Maartje; Vermeulen, Roel; de Jongste, Johan C; van Rossem, Lenie; Vonk, Judith M; Wijga, Alet; Huss, Anke; Gehring, Ulrike (2017-10-01)
      Agricultural pesticides are frequently used for crop protection. Residents living in close proximity to treated fields may be exposed to these pesticides. There is some indication that children living near agricultural fields have an increased risk of developing asthma and decreased lung function.
    • Proximity to livestock farms and exposure to livestock-related particulate matter are associated with lower probability of medication dispensing for obstructive airway diseases.

      Post, Pim M; Houthuijs, Danny; Sterk, Hendrika A M; Marra, Marten; van de Kassteele, Jan; van Pul, Addo; Smit, Lidwien A M; van der Hoek, Wim; Lebret, Erik; Hogerwerf, Lenny (2020-10-28)
      A nationwide population-based cross-sectional study was conducted among 7,735,491 persons, with data on the dispensing of drugs for obstructive airway diseases in the Netherlands in 2016. Exposure was based on distances between home addresses and farms and on modelled atmospheric particulate matter (PM10) concentrations from livestock farms. Data were analysed for different regions by logistic regression analyses and adjusted for several individual-level variables, as well as modelled PM10 concentration of non-farm-related air pollution. Results for individual regions were subsequently pooled in meta-analyses.
    • Psychometric properties of the Dutch version of the Hospital-level Consumer Assessment of Health Plans Survey instrument.

      Arah, Onyebuchi A; Asbroek, A H A ten; Delnoij, Diana M J; de Koning, Johan S; Stam, Piet J A; Poll, Aldien H; Vriens, Barbara; Schmidt, Paul F; Klazinga, Niek S (2006-02-01)
      OBJECTIVES: To assess the reliability and validity of a translated version of the American Hospital-level Consumer Assessment of Health Plans Survey (H-CAHPS) instrument for use in Dutch health care. DATA SOURCES/STUDY SETTING: Primary survey data from adults aged 18 years or more who were recently discharged from two multispecialty city hospitals in the Netherlands. STUDY DESIGN: We used forward and backward translation procedures and a panel of experts to adapt the 66-item pilot H-CAHPS into a 70-item Dutch instrument. Descriptive statistics and standard psychometric methods were then used to test the reliability and validity of the new instrument. DATA COLLECTION: From late November 2003 to early January 2004, the survey was administered by mail to 1,996 patients discharged within the previous 2 months. PRINCIPAL FINDINGS: Analyses supported the reliability and validity of the following 7-factor H-CAHPS structure for use in Dutch hospitals: on doctor's communication, nurses' communication, discharge information, communication about medication, pain control, physical environment of hospital, and nursing services. The internal consistency reliability of the scales ranged from 0.60 to 0.88. Items related to "family receiving help when on visit,""hospital staff introducing self," and "admission delays" did not improve the psychometric properties of the new instrument. CONCLUSIONS: These findings suggest that the H-CAHPS instrument is reliable and valid for use in the Dutch context. However, more research will be needed to support its equivalence to the United States version, and its use for between-hospital comparisons.
    • Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses.

      van Tuijl, Lonneke A; Voogd, Adri C; de Graeff, Alexander; Hoogendoorn, Adriaan W; Ranchor, Adelita V; Pan, Kuan-Yu; Basten, Maartje; Lamers, Femke; Geerlings, Mirjam I; Abell, Jessica G; et al. (2021-09-02)
    • Pubertal Timing and Cardiometabolic Markers at Age 16 Years.

      Berentzen, Nina E; Wijga, Alet H; van Rossem, Lenie; Postma, Dirkje S; Gehring, Ulrike; Smit, Henriëtte A (2017-08)
      To examine the association between pubertal timing and cardiometabolic markers among adolescents.
    • Public Health Citizen Science; Perceived Impacts on Citizen Scientists: A Case Study in a Low-Income Neighbourhood in the Netherlands

      Den Broeder, Lea; Lemmens, Lidwien; Uysal, Serfanim; Kauw, Karin; Weekenborg, Jitske; Schönenberger, Michaela; Klooster-Kwakkelstein, Simone; Schoenmakers, Mieke; Scharwächter, Willie; Van de Weerd, Annemarije; et al. (2017-11-09)