• Immunogenicity of pneumococcal vaccination in HIV infected individuals: A systematic review and meta-analysis.

      Garrido, Hannah M Garcia; Schnyder, Jenny L; Tanck, Michael W T; Vollaard, Albert; Spijker, René; Grobusch, Martin P; Goorhuis, Abraham (2020-11-23)
      The systematic review protocol was published online (PROSPERO ID: CRD 42020153137). We searched Medline (Ovid), EMBASE (Ovid), and the Global Health Library for publications from 2000 to June 11, 2020. We included all studies in adult PLWH that reported vaccine immunogenicity outcomes. The primary outcome was seroconversion rate (SCR) after PCV, PPSV and PCV/PPSV combined. For random-effects meta-analysis, we included studies defining SCR as a ≥ 2-fold increase in IgG from baseline, and reporting SCR for serotypes 6B, 14, or overall SCR, 1-3 months after vaccination.