• External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort.

      Lamain-de Ruiter, Marije; Kwee, Anneke; Naaktgeboren, Christiana A; Louhanepessy, Rebecca D; De Groot, Inge; Evers, Inge M; Groenendaal, Floris; Hering, Yolanda R; Huisjes, Anjoke J M; Kirpestein, Cornel; et al. (2019-03-20)
      To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.