• Air pollution and IgE sensitization in four European birth cohorts - the MeDALL project.

      Melén, Erik; Standl, Marie; Gehring, Ulrike; Altug, Hicran; Antó, Josep Maria; Berdel, Dietrich; Bergström, Anna; Bousquet, Jean; Heinrich, Joachim; Koppelman, Gerard H; et al. (2020-09-11)
      Up to 6163 children from four European birth cohorts participating in the MeDALL Consortium were included in this meta-analysis: BAMSE (Sweden), LISA/GINIplus (Germany), and PIAMA (The Netherlands). Individual residential outdoor levels of particulate matter with aerodynamic diameters <2.5, <10, 2.5-10 μm, PM2.5 absorbance, nitrogen oxides were modelled by land-use regression. Blood samples drawn at 4-6 (n=5989), 8-10 (n=6603) and 15-16 (n=5825) years were analyzed for IgE sensitization to allergen extracts by ImmunoCAP. Additionally, IgE against 132 allergen molecules was measured using the MedALL microarray chip (n=1021).
    • Air pollution and the development of asthma from birth until young adulthood.

      Gehring, Ulrike; Wijga, Alet H; Koppelman, Gerard H; Vonk, Judith M; Smit, Henriette A; Brunekreef, Bert (2020-07-01)
      We used data of 3687 participants of the prospective Dutch PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort and linked asthma incidence until age 20 years to estimated concentrations of nitrogen dioxide (NO2), particulate matter with a diameter <2.5 μm (PM2.5), <10 μm (PM10), and 2.5-10 μm, and PM2.5 absorbance ("soot") at the residential address. We assessed overall and age-specific associations with air pollution exposure with discrete time-hazard models, adjusting for potential confounders.
    • Air pollution during New Year's fireworks and daily mortality in the Netherlands.

      Greven, Frans E; Vonk, Judith M; Fischer, Paul; Duijm, Frans; Vink, Nienke M; Brunekreef, Bert (2019-04-05)
      Short-term exposure to air pollution has been associated with cardiovascular and respiratory mortality and morbidity. Little is known about associations between air pollution caused by firework events and daily mortality. We investigated whether particulate matter from fireworks during New Year's celebrations was associated with daily mortality. We analyzed the celebrations of the years 1995-2012. PM
    • Air pollution exposure and lung function until age 16 years: the PIAMA birth cohort study.

      Milanzi, Edith B; Koppelman, Gerard H; Smit, Henriette A; Wijga, Alet H; Oldenwening, Marieke; Vonk, Judith M; Brunekreef, Bert; Gehring, Ulrike (2018-09)
      Evidence for the effects of air pollution exposure on lung function growth into adolescence is scarce. We investigated associations of air pollution exposure with lung function and lung function growth until age 16.We conducted both longitudinal (n=915) and cross-sectional (n=721) analyses of associations of air pollution exposure with forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) growth from ages eight to 16 and FEV1 and FVC at age 16. We estimated residential concentrations of nitrogen dioxide (NO2), "soot" and particulate matter (PMx, where x is the 50% cut-off aerodynamic diameter in µm) with diameters of <2.5 µm (PM2.5), <10 µm (PM10) and 2.5-10 µm (PMcoarse) during the preschool, primary school and secondary school time windows by land use regression models. Associations with (growth in) FEV1 and FVC were analysed by linear (mixed effects) regression.Higher air pollution exposure was associated with reduced FEV1 growth (e.g. adjusted difference -0.26% (95% CI -0.49 to -0.03%) per interquartile range increase in secondary school PM2.5) and lower FEV1 (adjusted difference -2.36% (95% CI -3.76 to -0.94%)), but was not adversely associated with FVC. Associations with FEV1 were stronger in boys than girls and were not modified by asthma status.Higher air pollution exposure may lead to increased airway obstruction, but not reduced lung volume in adolescence.
    • Genetic risk scores do not improve asthma prediction in childhood.

      Dijk, F Nicole; Folkersma, Charlotte; Gruzieva, Olena; Kumar, Ashish; Wijga, Alet H; Gehring, Ulrike; Kull, Inger; Postma, Dirkje S; Vonk, Judith M; Melén, Erik; et al. (2019-05-27)
    • Green Space Visits among Adolescents: Frequency and Predictors in the PIAMA Birth Cohort Study.

      Bloemsma, Lizan D; Gehring, Ulrike; Klompmaker, Jochem O; Hoek, Gerard; Janssen, Nicole A H; Smit, Henriëtte A; Vonk, Judith M; Brunekreef, Bert; Lebret, Erik; Wijga, Alet H (2018)
      Green space may influence health through several pathways, for example, increased physical activity, enhanced social cohesion, reduced stress, and improved air quality. For green space to increase physical activity and social cohesion, spending time in green spaces is likely to be important.
    • Healthcare utilisation and expenditure of overweight and non-overweight children.

      Wijga, Alet H; Mohnen, Sigrid M; Vonk, Judith M; Uiters, Ellen (2018-06-11)
      Quantification of the burden of overweight on the healthcare system is becoming increasingly urgent for health policy, but accurate estimates are hard to obtain.
    • House dust endotoxin, asthma and allergic sensitization through childhood into adolescence.

      Gehring, Ulrike; Wijga, Alet H; Koppelman, Gerard H; Vonk, Judith M; Smit, Henriëtte A; Brunekreef, Bert (2020-07-08)
      We used data of 854 participants of the prospective Dutch PIAMA birth cohort study with house dust endotoxin measurements at 3 months and/or 5-6 years and data on asthma and/or allergic sensitization from at least one of 11 follow-ups until age 17. We assessed overall and age-specific associations of the prevalence of asthma and sensitization with mattress and living room floor dust concentrations (per gram of dust) and loads (per m2 of sampling surface).
    • Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts.

      Paternoster, Lavinia; Savenije, Olga E M; Heron, Jon; Evans, David M; Vonk, Judith M; Brunekreef, Bert; Wijga, Alet H; Henderson, A John; Koppelman, Gerard H; Brown, Sara J (2018-03)
      Atopic dermatitis (AD) is a prevalent disease with variable natural history. Longitudinal birth cohort studies provide an opportunity to define subgroups on the basis of disease trajectories, which may represent different genetic and environmental pathomechanisms.
    • The joint effect of maternal smoking during pregnancy and maternal pre-pregnancy overweight on infants' term birth weight.

      Chattrapiban, Thanin; Smit, Henriette A; Wijga, Alet H; Brunekreef, Bert; Vonk, Judith M; Gehring, Ulrike; van Rossem, Lenie (2020-02-27)
    • Proximity to agricultural fields as proxy for environmental exposure to pesticides among children: The PIAMA birth cohort.

      Bukalasa, Joseph S; Brunekreef, Bert; Brouwer, Maartje; Vermeulen, Roel; de Jongste, Johan C; van Rossem, Lenie; Vonk, Judith M; Wijga, Alet; Huss, Anke; Gehring, Ulrike (2017-10-01)
      Agricultural pesticides are frequently used for crop protection. Residents living in close proximity to treated fields may be exposed to these pesticides. There is some indication that children living near agricultural fields have an increased risk of developing asthma and decreased lung function.
    • Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence.

      Milanzi, Edith B; Koppelman, Gerard H; Smit, Henriette A; Wijga, Alet H; Vonk, Judith M; Brunekreef, Bert; Gehring, Ulrike (2019-10-01)
    • Timing of secondhand smoke, pet, dampness or mould exposure and lung function in adolescence.

      Milanzi, Edith B; Koppelman, Gerard H; Smit, Henriette A; Wijga, Alet H; Vonk, Judith M; Brunekreef, Bert; Gehring, Ulrike (2019-11-20)
      We used data from participants of the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort with spirometric measurements at ages 12 and 16 years (n=552). Data on residential exposure to SHS, pets, and dampness or mould were obtained by repeated parental questionnaires. We characterised timing of exposure through longitudinal patterns using latent class growth modelling and assessed associations of these patterns with FEV1 and FVC at ages 12 and 16 and FEV1 and FVC growth between ages 12 and 16 using linear regression models.