• Circulation of Bordetella pertussis in the Caribbean Netherlands: a population-based seroepidemiological study.

      Immink, Maarten M; Vos, Eric R A; Janga-Jansen, Alcira V A; Baboe-Kalpoe, Sharda; Hulshof, Koen; van Vliet, Jeffrey; Kerkhof, Jeroen; den Hartog, Gerco; de Melker, Hester E; van der Klis, Fiona R M; et al. (2021-08-15)
    • High varicella zoster virus susceptibility in Caribbean island populations: Implications for vaccination.

      Vos, Regnerus A; Mollema, Liesbeth; van Boven, Michiel; van Lier, Alies; Smits, Gaby; Janga-Jansen, Alcira V A; Baboe-Kalpoe, Sharda; Hulshof, Koen; Stienstra, Ymkje; van der Klis, Fiona R M; et al. (2020-05-01)
    • Risk of Measles and Diphtheria Introduction and Transmission on Bonaire, Caribbean Netherlands, 2018.

      Vos, Regnerus A; Mollema, Liesbeth; Kerkhof, Jeroen; van den Kerkhof, Johannes H C T; Gerstenbluth, Izzy; Janga-Jansen, Alcira V A; Stienstra, Ymkje; de Melker, Hester E; van der Klis, Fiona R M (2019-07-01)
      Endemic transmission of measles has been reestablished in Venezuela, and outbreaks of diphtheria remain ongoing across Latin America (LA). Hence, a large cross-sectional population-based serosurveillance study was conducted on Bonaire, one of the Dutch Leeward Antilles, to assess specific age and population groups at risk. Participants (aged 0-90 years) donated a blood sample and completed a questionnaire (n = 1,129). Antibodies against measles and diphtheria were tested using bead-based multiplex immunoassays. Our data revealed that immunity against measles is suboptimal, especially for those aged less than 5 years from Suriname, Aruba, and former Dutch Antilles (SADA), and adolescents from LA; and against diphtheria for persons aged more than 30 years, particularly among females and residents from SADA and LA. As refugees arrive persistently, health authorities on the Dutch Leeward Antilles should be on alert to detect early cases and prevent subsequent transmission. Ultimately, there is an urgent need for serosurveillance studies in the Caribbean region.
    • Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands.

      Vos, Regnerus A; Mollema, Liesbeth; van Binnendijk, Rob; Veldhuijzen, Irene K; Smits, Gaby; Janga-Jansen, Alcira V A; Baboe-Kalpoe, Sharda; Hulshof, Koen; van der Klis, Fiona R M; Melker, Hester E de (2019-10-01)
      The National Immunization Program (NIP) on Bonaire, St. Eustatius and Saba (i.e., Caribbean Netherlands (CN)) includes the measles-mumps-rubella (MMR) vaccine since 1988/89. Seroepidemiological data is an important tool to evaluate the NIP, hence a cross-sectional representative population-based serosurveillance study was conducted for the first time in CN in mid-2017. Participants (n = 1829, aged 0-90 years) donated a blood sample and completed a health-related questionnaire. MMR-specific IgG antibodies were determined using a bead-based multiplex immunoassay and risk factors were analyzed using logistic regression models. Overall seroprevalence was high for measles (94%), but lower for mumps and rubella (both 85%). In NIP eligibles, including women of childbearing age, rubella seroprevalence (88%) exceeded the threshold for protection (85%); however, for measles (89%) this protective level (95%) was not met. MMR seropositivity was lowest in children who became CN resident at 11-17 years of age (especially for measles (72%)), mostly originating from Latin America and other non-Western countries. Interestingly, rubella seroprevalence was lowest in non-NIP eligible adults from Dutch overseas territories and Suriname (75%). Taken together, MMR immunity is generally good in CN, nonetheless some risk groups were identified. Additionally, we found evidence for a unique island epidemiology. In light of recent regional measles outbreaks, disease monitoring remains of utmost importance.