• Circulation of Bordetella pertussis in the Caribbean Netherlands: a population-based seroepidemiological study.

      Immink, Maarten M; Vos, Eric R A; Janga-Jansen, Alcira V A; Baboe-Kalpoe, Sharda; Hulshof, Koen; van Vliet, Jeffrey; Kerkhof, Jeroen; den Hartog, Gerco; de Melker, Hester E; van der Klis, Fiona R M; et al. (2021-08-15)
    • High varicella zoster virus susceptibility in Caribbean island populations: Implications for vaccination.

      Vos, Regnerus A; Mollema, Liesbeth; van Boven, Michiel; van Lier, Alies; Smits, Gaby; Janga-Jansen, Alcira V A; Baboe-Kalpoe, Sharda; Hulshof, Koen; Stienstra, Ymkje; van der Klis, Fiona R M; et al. (2020-05-01)
    • Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands.

      Vos, Regnerus A; Mollema, Liesbeth; van Binnendijk, Rob; Veldhuijzen, Irene K; Smits, Gaby; Janga-Jansen, Alcira V A; Baboe-Kalpoe, Sharda; Hulshof, Koen; van der Klis, Fiona R M; Melker, Hester E de (2019-10-01)
      The National Immunization Program (NIP) on Bonaire, St. Eustatius and Saba (i.e., Caribbean Netherlands (CN)) includes the measles-mumps-rubella (MMR) vaccine since 1988/89. Seroepidemiological data is an important tool to evaluate the NIP, hence a cross-sectional representative population-based serosurveillance study was conducted for the first time in CN in mid-2017. Participants (n = 1829, aged 0-90 years) donated a blood sample and completed a health-related questionnaire. MMR-specific IgG antibodies were determined using a bead-based multiplex immunoassay and risk factors were analyzed using logistic regression models. Overall seroprevalence was high for measles (94%), but lower for mumps and rubella (both 85%). In NIP eligibles, including women of childbearing age, rubella seroprevalence (88%) exceeded the threshold for protection (85%); however, for measles (89%) this protective level (95%) was not met. MMR seropositivity was lowest in children who became CN resident at 11-17 years of age (especially for measles (72%)), mostly originating from Latin America and other non-Western countries. Interestingly, rubella seroprevalence was lowest in non-NIP eligible adults from Dutch overseas territories and Suriname (75%). Taken together, MMR immunity is generally good in CN, nonetheless some risk groups were identified. Additionally, we found evidence for a unique island epidemiology. In light of recent regional measles outbreaks, disease monitoring remains of utmost importance.